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Protocol· 6 min read

CJC-1295 / Ipamorelin: The Definitive Research Stack Guide

The CJC-1295 (no DAC) and Ipamorelin stack is the most commonly studied growth-hormone-releasing protocol in peptide research. It pairs a short-acting GHRH analog with a selective ghrelin mimetic to produce a clean, pulsatile GH release that mirrors the body's own rhythm.

Why the stack works

CJC-1295 (no DAC) is a GHRH analog — it tells the pituitary to release GH. Ipamorelin is a GHRP (growth hormone releasing peptide) that activates the ghrelin receptor through a different pathway. Together they produce a larger, cleaner GH pulse than either peptide alone, while Ipamorelin's selectivity avoids the cortisol and prolactin spikes seen with older GHRPs like GHRP-6.

Dosing schedule

Standard research protocol is 100 mcg CJC-1295 (no DAC) + 100–200 mcg Ipamorelin per injection. The most-studied timing is pre-bed (to amplify the natural overnight GH pulse) and optionally post-workout. Both peptides have ~30 minute half-lives, mimicking the natural GH pulse window.

Expected research outcomes

Most studied effects appear in this order: improved sleep depth (week 1–2), enhanced recovery (week 2–3), skin and collagen improvements (week 4+), lean mass gain and body fat reduction (week 6–12). Effects plateau around the 12-week mark; researchers typically run 12-week on / 4-week off cycles.

Cost per month

At Atlas Labs research pricing, the combined CJC-1295/Ipamorelin vial is $100. A typical research month uses 1 vial. Bulk discounts (10% at 3 vials, 15% at 6 vials) bring the per-month cost down meaningfully on a 12-week protocol.

Common research stacks

CJC/Ipamorelin is frequently stacked with BPC-157 (recovery research), Tesamorelin (visceral fat research), or IGF-1 LR3 (anabolic research). These pairings target different parts of the GH/IGF-1 axis and are extensively documented in published peptide literature.

Peptides referenced in this guide

Frequently asked questions

How long until CJC-1295 / Ipamorelin works?+

Sleep effects within 1–2 weeks. Body composition changes typically take 6–12 weeks of consistent pre-bed dosing.

Should I take CJC-1295 with or without DAC?+

Without DAC for pulsatile dosing — it mimics the body's natural GH rhythm. CJC-1295 with DAC produces a sustained GH elevation, which has its own research use cases but is not preferred for pulse-mimicking protocols.

Do you need to cycle CJC-1295 / Ipamorelin?+

Published research protocols typically use 12 weeks on, 4 weeks off to preserve pituitary sensitivity. Long-term continuous dosing has not been well-studied.

More research guides